Discontinuation of disease-modifying treatments in multiple sclerosis to plan a pregnancy: A retrospective registry study

Publication date: November 2020Source: Multiple Sclerosis and Related Disorders, Volume 46Author(s): Ramón Villaverde-González, Antonio Candeliere-Merlicco, María Aránzazu Alonso-Frías, Eladio Aparicio Castro, Andrés Carrillo Alcaraz, Javier Mallada Frechín, Ángel Pérez Sempere
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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Conclusion Our findings indicate that pregnancy before symptom onset does not modify the risk of MS in genetically susceptible White females.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Autonomic diseases, Multiple sclerosis, Risk factors in epidemiology, All Genetics Article Source Type: research
HORSHAM, PA, September 30, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today that the U.S. Food and Drug Administration (FDA) has approved SIMPONI ARIA® (golimumab) for patients 2 years of age and older for the treatment of active pJIA and has extended the PsA indication for this same patient population. “This latest FDA approval of SIMPONI ARIA for pediatric use in active pJIA and active PsA not only brings a new option to young patients living with these diseases but also adds to the growing body of evidence for this treatment,” said Mathai Mammen, M.D., Ph.D., Glob...
Source: Johnson and Johnson - Category: Pharmaceuticals Source Type: news
The effect of pregnancy hormone estriol (E3) on innate and adaptive immunity cells functions in patients with multiple sclerosis (MS) in comparison with healthy donors (HD) was studied. E3 inhibited phagocytic activity of neutrophils and enhanced monocytes IDO activity. Treg percentage increased and number of Th17 and iNKT cells decreased under E3 influence. At the same time, E3 stimulated production of IL-10 and inhibited secretion of IL-17. The hormonal effects were realized on the cells of both HD and MS patients.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Syndicated CBSN Boston CNN FDA Source Type: news
If you ask health care providers about the most challenging condition to treat, chronic pain is mentioned frequently. By its nature, chronic pain is a complex and multidimensional experience. Pain perception is affected by our unique biology, our mood, our social environment, and past experiences. If you or a loved one is suffering from chronic pain, you already know the heavy burden. People are looking for novel, nonaddictive ways to treat pain Given the ongoing challenges of chronic pain management coupled with the consequences of the opioid epidemic, pain management practitioners and their patients are searching for eff...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Back Pain Marijuana Pain Management Source Type: blogs
TUESDAY, Sept. 22, 2020 -- Pregnancy is associated with a delay in the onset of multiple sclerosis by more than three years, according to a study published online Sept. 14 in JAMA Neurology. Ai-Lan Nguyen, M.B.B.S., from the Royal Melbourne...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
FRIDAY, Sept. 18, 2020 -- Pregnancy can delay the onset of multiple sclerosis (MS) by more than three years, researchers report. The international study found those who'd been pregnant had their first MS symptoms an average of 3.3 years later than...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
A study on 3,600 women living in the Czech Republic and Australia revealed women who were pregnant developed the condition on average 3.3 years later than their counterparts.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Biological sex-related factors are associated with the risk of developing multiple sclerosis (MS), with contemporary incident cases occurring among female individuals at a 3-fold higher rate than among male individuals. Although specific genes on the X chromosome may play a modest role in MS susceptibility and severity, reproductive factors, including sex steroid hormone production and pregnancy, have long been recognized to alter the disease course in MS. Onset of pediatric MS becomes prominent at approximately age 13 years, just after children enter puberty. Girls typically present at least 2 years after menarche, and th...
Source: JAMA Neurology - Category: Neurology Source Type: research
CONCLUSION: Physicians and patients should be aware of the updated recommendations for UTis and MS. PMID: 32900473 [PubMed - as supplied by publisher]
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
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