Increasing use of linezolid in a tertiary NICU during a 10-year period: reasons and concerns for the future

ConclusionsA rapid increase in linezolid prescriptions has been observed in our tertiary NICU, from 2014 to 2019, with 33% inadequate uses. This worrisome trend should lead to search for therapeutic alternatives and to work on antibiotic stewardship to prevent the emergence of new antimicrobial bacterial resistance.
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research

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Publication date: Available online 8 October 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): E.L. Looman, P. van Tienen, D.Y.K. Ng, S. Baig, A. Fait, S. Overballe-Petersen, P.S. Andersen, M. Stegger
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
AbstractThe present study aimed to provide a detailed characterization of coagulase-negative staphylococci (CoNS) isolated from cows and buffaloes with mastitis. The study included seventy-five CoNS isolates (60 came from cattle and 15 from buffaloes) originating from 68 individual quarters of 67 dairy cows (53 cattle and 14 buffaloes). The animals belonged to five different small holding dairy herds (n = 140 cows) that show clinical or subclinical mastitis. CoNS isolates were phenotypically characterized using MALDI-TOF-MS and were further genotypically characterized by microarray-based assays. Furthermore, ...
Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
ConclusionOur findings reveal a distinct susceptibility pattern across the various study regions in Africa, with notably high rates of ESBL-producing Enterobacterales and ciprofloxacin-resistant nt Salmonella in Burkina Faso. This highlights the need for local AMR surveillance and reporting of resistances to support appropriate action.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Abstract Poly(2-oxazoline)s have excellent biocompatibility and have been used as a FDA-approved indirect food additive. The inert property of the hydrophilic poly(2-oxazoline)s suggests them as promisingsubstitution of PEG in variable applications such as resisting biofouling. Recently, Liu group reported that poly(2-oxazoline)s themselves have antimicrobial properties as synthetic mimics of host defense peptides. These studies revealed the bioactive properties of poly(2-oxazoline)s as a new class of functional peptide mimics, by mimicking host defense peptide to display potent and selective antimicrobial activit...
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research
Abstract Staphylococcus aureus is an opportunistic pathogen leading to food poisoning as well as human infections. The present study examined the prevalence and characterization of antimicrobial-resistant S. aureus in sushi from 42 outlets and in pork products from eight outlets in Beijing, China. The total bacterial counts were between 3.0 and 8.9 log CFU/g (mean 5.5 ± 1.5 log CFU/g) in sushi products and 4.8 to 7.4 log CFU/g (mean 5.6 ± 0.8 log CFU/g) in pork products. The mean counts of coliforms were 2.7 and 2.9 log CFU/g in su...
Source: Food Microbiology - Category: Food Science Authors: Tags: Food Microbiol Source Type: research
Publication date: December 2020Source: Journal of Global Antimicrobial Resistance, Volume 23Author(s): P. Moreno Mochi, J.M. Vargas, S. Vivaldo, M. Bottiglieri, C. López, S. Mochi, M. Cobos, M. Castillo, R. del Campo, M.A. Jure
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
In this study, a wide genetic diversity of strains of S. aureus from different foods, humans, and animals was found. This demonstrates evolution, genetic versatility, and, therefore, the adaptation of this microorganism in different environments. PMID: 32908519 [PubMed]
Source: International Journal of Microbiology - Category: Microbiology Tags: Int J Microbiol Source Type: research
BackgroundFebrile illness is the commonest cause of hospitalization in children four million genomes/μL) of P. falciparum in plasma. Overall, in-hospital death was 4% (89/2,146), and it was higher in children with bacteraemia (8%, 18/227) than malaria (2%, 4/194, p = 0.007). Risk factors for death were bacteraemia (p = 0.03), unconsciousness at admission (p
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Authors: Lupia T, Corcione S, Mornese Pinna S, De Rosa FG Abstract The burden of hospital admission for pneumonia in internal medicine wards may not be underestimated; otherwise, cases of pneumonia are a frequent indication for antimicrobial prescriptions. Community- and hospital-acquired pneumonia are characterized by high healthcare costs, morbidity and non-negligible rates of fatality. The overcoming prevalence of resistant gram-negative and positive bacteria (e.g., methicillin-resistant Staphylococcus aureus, penicillin and ceftriaxone-resistant Streptococcus pneumoniae, extended-spectrum β-lactamases and ...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
ConclusionsAn increased fosfomycin resistance rate of MRSA isolates was observed in our present study, mostly due to mutations in theglpT anduhpT genes. Clonal spread probably contributed to the increased fosfomycin resistance.
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research
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