NKG2D-Fc fusion protein promotes antitumor immunity through the depletion of immunosuppressive cells

In conclusion, NKG2D-Fc induces antitumor immunity and tumor control through the depletion of MDSCs and Tregs, subsequently providing a niche for the infiltration and expansion of proinflammatory cells, such as NK cells. Strategies capable of modulating the immunosuppressive state in cancer are in high clinical demand. NK G2D-Fc is a simple, single tool capable of depleting both MDSCs and Tregs and should be further investigated as a therapeutic agent for the treatment of cancer.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research