Cryptotanshinone Protects Porcine Alveolar Macrophages from Infection with Porcine Reproductive and Respiratory Syndrome Virus.

We report that the natural compound cryptotanshinone (Cpt) effectively inhibits the PRRSV infection of porcine alveolar macrophages (PAMs), the primary cell target of PRRSV in vivo. Mechanistically, Cpt inhibits the activation of signal transducer and activator of transcription 3 (STAT3), and blocks the interleukin 10 (IL-10) stimulated as well as the basal level expression of CD163 in PAMs. Cpt-treatment of PAMs is effective either pre- or post-PRRSV infection, resulting in significantly inhibited PRRSV infection in a dose-dependent manner. Our study identified a new route to prevent/treat PRRSV infection of pigs by using natural compounds. PMID: 32961199 [PubMed - as supplied by publisher]
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research