Combination of Captopril with Gliclazide Decreases Vascular and Renal Complications and Improves Glycemic Control in Rats with Streptozotocin-induced Diabetes Mellitus.

CONCLUSIONS: Captopril showed a promising protective effect against DM vascular complications, at least via nitric oxide modulating effect, antioxidant effect and anti-inflammatory activity that appeared in biochemical and histopathological findings, lipid profile, renal function and architecture improvements. Combining gliclazide with captopril gives an additive effect through enhanced glycemic control and increased anti-oxidant and anti-inflammatory properties above captopril alone. PMID: 32955003 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research