Impact of loading dose of caspofungin in PK/PD target attainment for severe candidiasis infections in ICU patients - the CASPOLOAD study.

CONCLUSION: A high loading dose of CAS (140mg) increased CAS exposure in the first 24 hours of therapy allowing early achievement of PK-PD targets for most Candida strains. Such strategy seems to improve treatment efficacy, even if further researches are needed to assess its impact on clinical outcomes. PMID: 32958709 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32958709?dopt=Abstract

Source: Antimicrobial Agents and Chemotherapy - September 20, 2020 Category: Microbiology Authors: Bailly S, Gautier-Veyret E, Lê MP, Bouadma L, Andremont O, Neuville M, Mourvillier B, Sonneville R, Magalhaes E, Lebut J, Radjou A, Smonig R, Wolff M, Massias L, Dupuis C, Timsit JF Tags: Antimicrob Agents Chemother Source Type: research