Imipenem plus fosfomycin as salvage therapy for vertebral osteomyelitis.

Imipenem plus fosfomycin as salvage therapy for vertebral osteomyelitis. Antimicrob Agents Chemother. 2020 Sep 21;: Authors: Nakamura I, Yamaguchi T, Aoki K, Miura Y, Sato S, Fujita H, Watanabe H Abstract We applied combination antibiotic therapy to treat vertebral osteomyelitis and a psoas abscess caused by glycopeptide-intermediate (MIC, 2 μg/ml) and daptomycin-non-susceptible (>2 μg/ml) methicillin-resistant Staphylococcus aureus The Etest synergy test showed the largest synergistic effects for imipenem/cilastatin and fosfomycin. Whole-gene sequencing showed amino acid changes in SA0802, SA1193 (mprF), and SA1531 (ald). Four weeks of combination treatment using imipenem/cilastatin (1.5 g per day) and fosfomycin (4.0 g per day) resulted in clinical improvement. PMID: 32958715 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research