Bone losses in obese, ovariectomized rats appear to be independent from sclerostin-induced inhibition of the Wnt/ β-catenin pathway.
CONCLUSIONS: Bone losses invoked by DIO seem to be independent from the Wnt/β-catenin pathway inhibition induced by sclerostin. While further study is necessary, the obtained results suggest that the usage of sclerostin anti-body in the treatment of osteoporosis can be ineffective, and in obese patients the undertaking of such therapy should be reassessed.
PMID: 32955221 [PubMed - in process]
Source: Annals of Agricultural and Environmental Medicine : AAEM - Category: Environmental Health Authors: Radzki RP, Bieńko M, Filip R, Polak P, Michalik Wolska J Tags: Ann Agric Environ Med Source Type: research
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