Presence of peripheral lesions and correlation to macular perfusion, oxygenation and neurodegeneration in early type ii diabetic retinal disease

Purpose: The impact of peripheral retinal lesions (PL) visualized with ultra–wide-field imaging on diabetic retinopathy (DR) remains unclear. The purpose of this study was to assess the presence of PL and their association with macular microvasculopathy, metabolic dysfunction, and neurodegeneration in patients with Type II diabetes and early retinal disease. Methods: Forty-five degree color fundus (Topcon) and 200° ultra–wide-field images (Optos) were assessed for the presence and severity of DR. Lesions anterior to the 45° were considered peripheral. The foveal avascular zone area, perimeter and acircularity index, and foveal full-retina and parafoveal superficial/deep complex vessel density were evaluated with RTVue optical coherence tomography angiography. Vessel oxygen saturation was measured with oximetry. Peripapillary retinal nerve fiber and individual macular retinal layer thicknesses were measured with Spectralis optical coherence tomography. Results: Among the 161 eyes (80 left eyes) of 81 patients (34 female), 64 (39.8%) showed higher levels of DR on ultra–wide-field than on 45° fundus images (P
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research