In Vivo Structural and Functional Abnormalities of the Striatums Is Related to Decreased Astrocytic BDNF in Itpr2-/- Mice Exhibiting Depressive-Like Behavior.
Conclusion: By combining biochemistry and MR analyses, this study provides evidences to support that the Itpr2-related neuropathological effect is possibly mediated by the striatal abnormality associated with dysfunctional astrocytes in Itpr2 -/- mice in vivo, thus may help us better understand underlying mechanisms of Itpr2 deficiency as well as its relation to depressive-like behavior.
PMID: 32952549 [PubMed - in process]
Source: Neural Plasticity - Category: Neurology Authors: Zeng S, Liu K, Zhang J, Chen C, Xu Y, Wu Y, Deng Y, Sun X, Wen G, Jing L Tags: Neural Plast Source Type: research