In Reply to Berk and Alfonso

We thank Drs. Alfonso and Berk for their interest1 in our meta-analysis of outcome data from randomized controlled trials of hypofractionated radiation therapy for low-risk prostate cancer.2 Specifically, we showed how the recently published study of ultrahypofractionated radiation therapy by Widmark et  al3 provides further evidence for a diminishing benefit from radiation therapy intensified by increasing the dose per fraction.2 This is a purely empirical observation and does not rely on any mechanistic assumptions.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comments Source Type: research