Rectal Spacer Usage with Proton Radiation Therapy for Prostate Cancer

First, and perhaps most importantly, Dinh et  al are to be applauded for presenting their prospective series of men treated with proton therapy at the University of Washington and their carefully reported rectal toxicity outcomes in the context of dose-volume histogram analysis as well as differing rectal immobilization devices.1 These result s provide strong evidence suggesting that without the use of a rectal spacer, there is increased rectal toxicity with proton therapy compared with intensity modulated radiation therapy (IMRT).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research

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Abstract The purpose of this study was the evaluation of the impact of a variable relative biological effectiveness (RBE) compared to a constant RBE value of 1.1 in proton therapy prostate trials due to uncertainties in α/β ratio.
 
 Twenty patients receiving passive scattered proton therapy (PSPT) and fifteen patients receiving intensity modulated proton therapy (IMPT) were compared to twenty patients treated with 7-field intensity modulated photon therapy (IMRT). For proton beam therapy (PBT), the RBE was estimated using two different RBE models. Tumor control probabilities (TCP) and n...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
Authors: Podder TK, Fredman ET, Ellis RJ Abstract Major categories of radiotherapy (RT) for prostate cancer (CaP) treatment are: (1) external beam RT (EBRT), and (2) brachytherapy (BT). EBRT are performed using different techniques like three-dimensional conformal RT (3D-CRT), intensity modulated RT (IMRT), volumetric modulated arc therapy (VMAT), and stereotactic body radiation therapy (SBRT), stereotactic radiosurgery (SRS) and intensity modulated proton therapy (IMPT), etc., using a variety of radiation delivery machines, such as a linear accelerator (Linac), Cyberknife robotic system, Gamma knife, Tomotherapy a...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
(Northwestern Memorial HealthCare) Proton therapy treatment for prostate cancer is associated with higher survival rates and decreased risk of complications compared to intensity-modulated radiation therapy (IMRT) according to a new study by researchers at the Northwestern Medicine Chicago Proton Center.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract Prostate cancer treatment with definitive radiation therapy (RT) has evolved dramatically in the past 2 decades. From the initial 2-dimensional planning using X-rays, advances in technology led to 3-dimensional conformal RT, which used computerized tomography-based planning. This has allowed delivery of higher doses of radiation to the prostate while reducing dose to the surrounding organs, resulting in improved cancer control. Today, intensity-modulated RT (IMRT) is considered standard, where radiation beams of different shapes and intensities can be delivered from a wide range of angles, thus further de...
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
CONCLUSIONS: Three-dimensional conformal radiotherapy has long been the standard of care for percutaneous radiotherapy. The development of intensity-modulated radiation therapy (IMRT) and image-guided radiation therapy (IGRT) have increased the precision of treatment, thus, reducing side effects and allowing dose escalation. LDR (low dose rate) and HDR (high dose rate) brachytherapy alone or in combination are a treatment option in localized prostate cancer with a distinct side effect profile. The roles of proton therapy and stereotactic radiotherapy should be further investigated in prospective trials. PMID: 26895435...
Source: Der Urologe. Ausg. A - Category: Urology & Nephrology Authors: Tags: Urologe A Source Type: research
To quantify and compare the impact of interfractional setup and anatomic variations on proton therapy (PT) and intensity modulated radiation therapy (IMRT) for prostate cancer.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Physics Contribution Source Type: research
Conclusions: Protons delivered comparable doses to targets in dose homogeneity and conformity and spared normal tissues from intermediate-to-low doses better than IMRT did. Further improvement of dose sparing and changes in homogeneity and conformity may be achieved by reducing proton range uncertainties and from implementing intensity modulation.
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Source Type: research
Hypofractionated radiation therapy (RT) yields similar rates of cure and side...Read more on AuntMinnie.comRelated Reading: Shortened RT for prostate cancer may not be better Prostate cancer rad therapy may cause other cancers Proton therapy succeeds in treating prostate cancer NEJM: Urologist self-referral equals IMRT overuse Prostate cancer patients get too much radiation therapy
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Hypofractionated radiation therapy (RT) isn't necessarily better for prostate...Read more on AuntMinnie.comRelated Reading: Prostate cancer rad therapy may cause other cancers Proton therapy succeeds in treating prostate cancer NEJM: Urologist self-referral equals IMRT overuse Prostate cancer patients get too much radiation therapy Proton therapy groups praise GAO prostate cancer report
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Proton therapy for the management of prostate cancer has been highly scrutinized because of its higher cost compared to photon based radiation therapies like intensity modulated radiation therapy (IMRT). The debate focuses on whether the benefits of proton therapy are worth the higher costs. If patients are treated with the same planning target volume margins, total dose (76 to 80 Gy) and target coverage, then proton therapy allows for a reduction in the radiation dose to the surrounding normal pelvic tissues in the low to moderate dose range of 0 to 50 Gy range compared to IMRT, while maintaining similar volumes of the or...
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Opposing Views Source Type: research
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