Comparison of anti-acetylcholine receptor profiles between Chinese cases of adult- and juvenile-onset myasthenia gravis using cell-based assays

Juvenile-onset myasthenia gravis (JOMG) is a unique clinical subtype in China, featured by a higher prevalence of ocular myasthenia gravis (OMG), higher seronegativity of acetylcholine receptor (AChR) antibodies, and better prognosis than that in adult-onset myasthenia gravis (AOMG). We previously identified low-affinity AChR antibodies in Chinese JOMG patients using cell-based assays (CBAs), indicating a predominantly AChR antibody-positive profile. Here, we further screened AChR antibodies in both Chinese AOMG and JOMG patients by CBAs.

Source: Journal of Neuroimmunology - September 20, 2020 Category: Allergy & Immunology Authors: Chong Yan, Rui Zhao, Jie Song, Xuelin Feng, Jianying Xi, Sushan Luo, Huahua Zhong, Shuizhen Zhou, Wenhui Li, Chongbo Zhao Source Type: research