Identification of profiles of volatile organic compounds in exhaled breath by means of an electronic nose as a proposal for a screening method for breast cancer: a case-control study
The objective of the present study was to identify volatile prints from exhaled breath, termed
breath-print, from breast cancer (BC) patients and healthy women by means of an electronic nose and
to evaluate its potential use as a screening method. A cross-sectional study was performed on 443
exhaled breath samples from women, of whom 262 had been diagnosed with BC by biopsy and 181 were
healthy women (control group). Breath-print analysis was performed utilizing the Cyranose 320
electronic nose. Group data were evaluated by principal component analysis (PCA), canonical
discriminant analysis (CDA), and support vector machine (SVM), and the test ’s diagnostic power was
evaluated by means of receiver operating characteristic (ROC) curves. The results obtained using the
model generated from the CDA, which best describes the behavior of the assessed groups, indicated
that the breath-print of BC patients was different from that of healthy women and that they
presented with a variabilit...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Lorena D íaz de León-Martínez, Maribel Rodríguez-Aguilar, Patricia Gorocica-Rosete, Carlos Alberto Domínguez-Reyes, Verónica Martínez-Bustos, Juan Alberto Tenorio-Torres, Omar Ornelas-Rebolledo, José Alfonso Cruz-Ramos, Berenice Balderas-Segura an Source Type: research
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