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COVID-19 carries significant morbidity and mortality for adults while children have been felt to be “spared”. The justification for the apparent difference in clinical response remains to be understood. We provide data pertinent to viral load, ACE2 expression and SARS-CoV-2 antibody responses for SARS-CoV-2-infected children1. Comparisons with adults probed for factors driving the apparent dic hotomous response between children and adults following infection with SARS-CoV-2. Our data show that children can, in fact, carry high viral loads despite mild symptoms, in contrast to adults who become quite ill even as viral load wanes.

Source: The Journal of Pediatrics - September 20, 2020 Category: Pediatrics Authors: Lael M. Yonker, Anne M. Neilan, Yannic Bartsch, Ankit B. Patel, James Regan, Puneeta Arya, Elizabeth Gootkind, Grace Park, Margot Hardcastle, Anita St. John, Lori Appleman, Michelle L. Chiu, Allison Fialkowski, Denis De La Flor, Rosiane Lima, Evan A. Bord Tags: Letters to the Editor Source Type: research