Cancers, Vol. 12, Pages 2705: Pathway-Based Integrative Analysis of Metabolome and Microbiome Data from Hepatocellular Carcinoma and Liver Cirrhosis Patients
Cancers, Vol. 12, Pages 2705: Pathway-Based Integrative Analysis of Metabolome and Microbiome Data from Hepatocellular Carcinoma and Liver Cirrhosis Patients
Cancers doi: 10.3390/cancers12092705
Authors:
Boram Kim
Eun Ju Cho
Jung-Hwan Yoon
Soon Sun Kim
Jae Youn Cheong
Sung Won Cho
Taesung Park
Aberrations of the human microbiome are associated with diverse liver diseases, including hepatocellular carcinoma (HCC). Even if we can associate specific microbes with particular diseases, it is difficult to know mechanistically how the microbe contributes to the pathophysiology. Here, we sought to reveal the functional potential of the HCC-associated microbiome with the human metabolome which is known to play a role in connecting host phenotype to microbiome function. To utilize both microbiome and metabolomic data sets, we propose an innovative, pathway-based analysis, Hierarchical structural Component Model for pathway analysis of Microbiome and Metabolome (HisCoM-MnM), for integrating microbiome and metabolomic data. In particular, we used pathway information to integrate these two omics data sets, thus providing insight into biological interactions between different biological layers, with regard to the host’s phenotype. The application of HisCoM-MnM to data sets from 103 and 97 patients with HCC and liver cirrhosis (LC), respectively, showed that this approach could identify HCC-related pathways related to cancer metabolic reprogramming, in addi...
Source: Cancers - Category: Cancer & Oncology Authors: Boram Kim Eun Ju Cho Jung-Hwan Yoon Soon Sun Kim Jae Youn Cheong Sung Won Cho Taesung Park Tags: Article Source Type: research
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