Cancers, Vol. 12, Pages 2709: Bortezomib-Loaded Mesoporous Silica Nanoparticles Selectively Alter Metabolism and Induce Death in Multiple Myeloma Cells
Cancers, Vol. 12, Pages 2709: Bortezomib-Loaded Mesoporous Silica Nanoparticles Selectively Alter Metabolism and Induce Death in Multiple Myeloma Cells
Cancers doi: 10.3390/cancers12092709
Authors:
Alessandra Nigro
Luca Frattaruolo
Mariarosa Fava
Ilaria De Napoli
Marianna Greco
Alessandra Comandè
Marzia De Santo
Michele Pellegrino
Elena Ricci
Francesca Giordano
Ida Perrotta
Antonella Leggio
Luigi Pasqua
Diego Sisci
Anna Rita Cappello
Catia Morelli
A mesoporous silica-based nanodevice bearing the antineoplastic drug bortezomib (BTZ), whose release is triggered in acidic environment and grafted with folic acid (FOL) as a targeting function (FOL-MSN-BTZ) was tested on folate receptor overexpressing (FR+) multiple myeloma (MM) cells and on FR negative (FR−) normal cells. FOL-MSN-BTZ efficacy studies were conducted by means of growth experiments, TEM, TUNEL assay and Western Blotting analysis (WB). Metabolic investigations were performed to assess cells metabolic response to MSNs treatments. FOL-MSN-BTZ exclusively killed FR+ MM cells, leading to an apoptotic rate that was comparable to that induced by free BTZ, and the effect was accompanied by metabolic dysfunction and oxidative stress. Importantly, FOL-MSN-BTZ treated FR− normal cells did not show any significant sign of injury or metabolic perturbation, while free BTZ was still highly toxic. Notably, the vehicle alone (MSN-FOL) did not affect any biological pro...
Source: Cancers - Category: Cancer & Oncology Authors: Alessandra Nigro Luca Frattaruolo Mariarosa Fava Ilaria De Napoli Marianna Greco Alessandra Comand è Marzia De Santo Michele Pellegrino Elena Ricci Francesca Giordano Ida Perrotta Antonella Leggio Luigi Pasqua Diego Sisci Anna Rita Cappello Catia Morell Tags: Article Source Type: research
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