Hyper ‐progressive disease after immune checkpoint inhibitor in SMARCA4‐deficient small‐cell lung carcinoma

Herein, we report a patient with SMARCA4 (switch/sucrose non ‐fermentable‐related, matrix‐associated, actin‐dependent regulator of chromatin, subfamily A, member 4)‐deficient small‐cell lung carcinoma (SCLC) who had hyper‐progressive disease (HPD) after the first immune checkpoint inhibitors (ICI) treatment. A 35‐year‐old man was treated wit h nivolumab, subsequent to cytotoxic chemotherapy. A week after nivolumab initiation, chest computed tomography revealed marked increase in pleural effusion in the right lung and chest wall dissemination of the tumour, which concur with the definition of HPD. This is the first study to report the oc currence of HPD after treatment with ICIs in a patient with SMARCA4‐deficient SCLC. Analysis of additional data is necessary to determine the optimal treatment for these patients. AbstractSMARCA4 (switch/sucrose non ‐fermentable‐related, matrix‐associated, actin‐dependent regulator of chromatin, subfamily A, member 4)‐deficient thoracic tumours have shown poor prognosis in clinical settings. Although the optimal treatment for SMARCA4‐deficient thoracic tumours remains unclear, existing studies indic ate a favourable response of these tumours to immune checkpoint inhibitors (ICIs). However, there are no reports of fatality in SMARCA4‐deficient small‐cell lung carcinoma (SCLC) with hyper‐progressive disease (HPD) upon treatment with ICIs. Herein, we report a patient with SMARCA4‐deficient SCLC who had HPD ...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research