Loss of FGFR3 accelerates bone marrow suppression-induced hematopoietic stem and progenitor cell expansion by activating FGFR1-ELK1-Cyclin D1 signaling

The chemotherapy or radiation therapy has been a major treatment for many types of diseases, especially malignant tumors 1. However, the two therapeutic ways often result in many side effects, especially bone marrow (BM) suppression 2, 3. Patients with BM suppression generate anemia and low immunity to aggravate the disease 3, 4. Leukemia patients that frequently had cytopenia or the dysfunction of normal blood cells produce higher mortality and morbidity 5-7. Therefore, it is urgent to strengthen hematopoietic regeneration in the process of therapy-induced BM suppression.

Source: Biology of Blood and Marrow Transplantation - September 19, 2020 Category: Hematology Authors: Qiuju Ran, Chen Guo, Chun Sun, Qing Liu, Haiting He, Wenjie Zhao, Jizhou Zhang, Yechen Xiao Source Type: research