Letters to the Editors: letter in response to Bhogal and colleagues.
Letters to the Editors: letter in response to Bhogal and colleagues.
J Thromb Haemost. 2020 Sep 18;:
Authors: Susen S, Rauch A, Lenting P
Abstract
We thank Bhogal and colleagues for their positive comments on our manuscript and their perspective on VWF being a potential driver of COVID-19 microvascular thrombosis rather than a mere biomarker of endotheliopathy. It is well-known that VWF promotes neutrophil recruitment to endothelial surfaces under low-shear conditions and supports neutrophil extravasation towards inflamed tissues1 . This pro-inflammatory role of VWF involves two distinct pathways: (1) a direct interaction of neutrophil receptors (PSGL1 and β2-integrins) with VWF, and (2) an indirect interaction in which neutrophils adhere to VWF-bound platelets.
PMID: 32945096 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Susen S, Rauch A, Lenting P Tags: J Thromb Haemost Source Type: research