Successful DAA therapy for chronic hepatitis C reduces HLA-DR on monocytes and circulating immune mediators: a long-term follow-up study.

CONCLUSIONS: Successful DAA therapy did not modify monocyte subsets frequency but reduced monocyte activation at 1y and sustained the downregulation and restoration of circulating immune mediators, indicating that long-term reversal of inflammation status could occur after HCV eradication.
PMID: 32946919 [PubMed - as supplied by publisher]

Source: Immunology Letters - September 14, 2020 Category: Allergy & Immunology Authors: Rosário NF, Saraiva GDN, Medeiros T, Gandini M, de Souza Lacerda G, Leite PEC, de Andrade TG, de Azeredo EL, Xavier AR, Silva AA Tags: Immunol Lett Source Type: research