Intranasal administration of Cytoglobin modifies human umbilical cord ‑derived mesenchymal stem cells and improves hypoxic‑ischemia brain damage in neonatal rats by modulating p38 MAPK signaling‑mediated apoptosis.

Intranasal administration of Cytoglobin modifies human umbilical cord‑derived mesenchymal stem cells and improves hypoxic‑ischemia brain damage in neonatal rats by modulating p38 MAPK signaling‑mediated apoptosis. Mol Med Rep. 2020 Aug 19;: Authors: Yang H, Tian S, Xie L, Chen Y, Ma L Abstract Neonatal hypoxic‑ischemic brain damage (HIBD) is a common clinical syndrome in newborns. Hypothermia is the only approved therapy for the clinical treatment; however, the therapeutic window of hypothermia is confined to 6 h after birth and even then,>40% of the infants either die or survive with various impairments, including cerebral palsy, seizure disorder and intellectual disability following hypothermic treatment. The aim of the present study was to determine whether nasal transplantation of Cytoglobin (CYGB) genetically modified human umbilical cord‑derived mesenchymal stem cells (CYGB‑HuMSCs) exhibited protective effects in neonatal rats with HIBD compared with those treated without genetically modified CYGB. A total of 120 neonatal Sprague‑Dawley rats (postnatal day 7) were assigned to either a Sham, HIBD, HuMSCs or CYGB‑HuMSCs group (n = 30 rats/group). For HIBD modeling, rats underwent left carotid artery ligation and were exposed to 8% oxygen for 2.5 h. A total of 30 min after HI, HuMSCs (or CYGB‑HuMSCs) labeled with enhanced‑green fluorescent protein (eGFP) were intranasally administered. After modeling for 3, 14 ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research

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This article summarizes the best available evidence interventions for preventing and managing cerebral palsy in 2019.Recent FindingsEffective prevention strategies include antenatal corticosteroids, magnesium sulfate, caffeine, and neonatal hypothermia. Effective allied health interventions include acceptance and commitment therapy, action observations, bimanual training, casting, constraint-induced movement therapy, environmental enrichment, fitness training, goal-directed training, hippotherapy, home programs, literacy interventions, mobility training, oral sensorimotor, oral sensorimotor plus electrical stimulation, pre...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
Abstract Neonatal ischemic brain injury causes permanent motor-deficit cerebral palsy. Hypoxic-ischemic encephalopathy (HIE) is a very serious condition that can result in death and disability. In 1997, we reported that irreversible neuronal cell damage is induced by the elevation of intracellular Ca ion concentration that has occurred in sequence after excess accumulation of the excitatory neurotransmitter glutamate during ischemia. We also reported that hypothermia was effective in treating ischemic brain damage in rats by suppressing energy loss and raising intracellular Ca ion concentration. Following the 2010...
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
Publication date: Available online 30 June 2017 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Christina L. Nemeth, Gabrielle T. Drummond, Manoj K. Mishra, Fan Zhang, Patrice Carr, Maxine S. Garcia, Sydney Doman, Ali Fatemi, Michael V. Johnston, Rangaramanujam M. Kannan, Sujatha Kannan, Mary Ann Wilson Perinatal hypoxic–ischemic encephalopathy (HIE) can result in neurodevelopmental disability, including cerebral palsy. The only treatment, hypothermia, provides incomplete neuroprotection. Hydroxyl polyamidoamine (PAMAM) dendrimers are being explored for targeted delivery of therapy for HIE. Unde...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Conclusions/Significance: In this nonhuman primate HIE model, animals treated with TH + Epo had less brain pathology noted on TBSS and IHC staining, which supports the long-term safety of TH + Epo in the setting of HIE. Animals that developed CP showed white-matter changes noted on TBSS, subtle histopathological changes in both the white and gray matter, and brainstem injury that correlated with CP severity. This HIE model may lend itself to further study of the relationship between brainstem injury and CP.Dev Neurosci
Source: Developmental Neuroscience - Category: Neuroscience Source Type: research
Neonatal encephalopathy (NE) is a major cause of neonatal mortality and morbidity. Therapeutic hypothermia (TH) is standard treatment for newborns at 36 weeks of gestation or greater with intrapartum hypoxia-related NE. Term and late preterm infants with moderate to severe encephalopathy show improved survival and neurodevelopmental outcomes at 18 months of age after TH. TH can increase survival without increasing major disability, rates of an IQ less than 70, or cerebral palsy. Neonates with severe NE remain at risk of death or severe neurodevelopmental impairment. This review discusses the evidence support...
Source: Clinics in Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research
BOSTON (CBS) – “The day you’re born might be the riskiest day of your life,” says Dr. Michael Prendergast, a neonatologist at Brigham and Women’s Hospital. “For most babies, thankfully this is a wonderful and healthy event but for some babies this is complicated by a period of reduced blood supply to the brain,” he adds. In an attempt to protect brain injury, doctors are now doing something that might sound strange. Within hours of birth, they’re wrapped in cooling blankets to lower their body temperature about four degrees below normal. It’s called therapeutic hypother...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Local News Seen On WBZ-TV Syndicated Local Watch Listen Brigham & Women's Hospital Dr. Mallika Marshall Dr. Michael Prendergast Source Type: news
ABSTRACT: Cognitive impairment is an important issue found in survivors at 18 to 24 months in all major previous trials of hypothermia treatment of hypoxic ischemic encephalopathy (HIE). The authors of this study hypothesized that infants between 18 and 22 months with a Mental Developmental Index of less than 70 would continue to have cognitive impairment and development disabilities at school age. The study aimed to report special educational services and therapies, describe the range of cognitive outcomes of moderate or severe HIE in children, and evaluate the value of various predictors of school-age cognition. Data fro...
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: Obstetrics: Newborn Medicine Source Type: research
Perinatal hypoxic ischemic encephalopathy (HIE) is a major cause of neurodevelopmental impairment including cerebral palsy and intellectual disability. Brain magnetic resonance imaging is the gold standard for acute assessment of cerebral injury in HIE. Limited data are available regarding the significance of clinically manifested neurobehavioral impairments in the neonatal period.
Source: Early Human Development - Category: Perinatology & Neonatology Authors: Source Type: research
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