Catalpol counteracts the pathology in a mouse model of Duchenne muscular dystrophy by inhibiting the TGF- β1/TAK1 signaling pathway.

In conclusion, catalpol can restore skeletal muscle strength and alleviate skeletal muscle damage in aged mdx mice, thus may provide a novel therapy for DMD. Catalpol attenuates muscle fibrosis by inhibiting the TGF-β1/TAK1 signaling pathway.
PMID: 32939036 [PubMed - as supplied by publisher]

Source: Acta Pharmacologica Sinica - September 15, 2020 Category: Drugs & Pharmacology Authors: Xu DQ, Zhao L, Li SJ, Huang XF, Li CJ, Sun LX, Li XH, Zhang LY, Jiang ZZ Tags: Acta Pharmacol Sin Source Type: research