Neuroimmune Cross Talk and Evolving Pharmacotherapies in Neurodegenerative Diseases.

Neuroimmune Cross Talk and Evolving Pharmacotherapies in Neurodegenerative Diseases. Immunology. 2020 Sep 16;: Authors: Baidya F, Bohra M, Datta A, Sarmah D, Shah B, Jagtap P, Raut S, Sarkar A, Singh U, Kalia K, Borah A, Wang X, Dave KR, Yavagal DR, Bhattacharya P Abstract Neurodegeneration is characterized by gradual onset and limited availability of specific biomarkers. Apart from various aetiologies like infection, trauma, genetic mutation, etc., the interaction between the immune system and CNS is widely associated with neuronal damage in neurodegenerative diseases. The immune system plays a distinct role in disease progression and cellular homeostasis. It induces cellular as well as humoral responses, enables tissue repair, cellular healing, and clearance of cellular detritus. Aberrant and chronic activation of the immune system can damage healthy neurons. The pro-inflammatory mediators secreted by chief innate immune components, the complement system, microglia, and inflammasome can augment cytotoxicity. Furthermore, these inflammatory mediators accelerate microglial activation resulting in progressive neuronal loss. Various animal studies have been carried out to unravel the complex pathology and ascertain biomarkers for these harmful diseases, but have had limited success. The present review will provide a thorough understanding of microglial activation, complement system, and inflammasome generation, which lead the healthy b...
Source: Immunology - Category: Allergy & Immunology Authors: Tags: Immunology Source Type: research