Assessment of a highly curated somatic oncology database to aid in the interpretation of clinically important variants in next-generation sequencing results
This study evaluated the accuracy of NAVIFY Mutation Profiler, a cloud-based CE-IVD software that aids in interpreting clinically relevant variants detected in somatic oncology next-generation sequencing (NGS) tests. This tool reports tiered classifications based on different levels of clinical evidence from a highly curated, regularly updated database derived from medical guidelines, drug approvals, and peer reviewed literature. A retrospective analysis was performed on NGS results from 37 lung cancer cases treated with chemotherapy (n=10), EGFR tyrosine kinase inhibitor (TKI) (n=5), or ALK TKI (n=22).
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Stephanie J. Yaung, Shuba Krishna, Liu Xi, Christine Ju, John F. Palma, Maximilian Schmid Tags: Regular Article Source Type: research
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