Oral nodular fasciitis: a case report
Nodular fasciitis (NF) is a rare and benign proliferation of fibroblasts and myofibroblasts that may be mistaken for a sarcoma due to clinically rapid growth, rich cellularity, and mitotic activity. A 14-year-old female was referred to the oral and maxillofacial surgery service with a nodular lesion in the tongue and 2 months ’ of evolution. Oral examination revealed a pedunculated nodule, 1.5 cm, pinkish, and irregular surface in the posterior tongue region. An excisional biopsy was performed, and the histopathologic analysis showed a proliferation of spindle cells arranged in fascicles, surrounded by dense connective tissue (keloid-like) and myxoid degeneration.
New J. Chem., 2020, Advance Article DOI: 10.1039/D0NJ02249G, PaperChuan-ce Sun, Li-chuan Zhang, Cheng-long Gao, Hao-ran Zhang, Ri-lei Yu, Cong-min Kang Serum and glucocorticoid-regulated protein kinase 1 that can promote the growth of tumor cells is highly expressed in many tumors. Sarcoma gene plays an important role in the pathogenesis of cancer and is an important kinase in tumor cell expression pathways. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
ConclusionRe-staging chest CT at the time of first LR of STS identified a prevalence of 23.9% pulmonary metastases, which supports the need for chest CT at the time of LR in line with the UK guidelines for the management of bone and soft tissue sarcoma.Key Points• Pulmonary metastases were diagnosed in 1.3% of soft tissue sarcomas at presentation.• Pulmonary metastases were identified in ~ 24% of patients at first local recurrence of soft tissue sarcoma, most commonly with pleomorphic sarcoma and Trojani grade tumours.• No patient with a low-grade recurrence had pulmonary metastases.
A patient affected by a voluminous synovial sarcoma of mediastinum received radical surgery, resulting in injury of both phrenic nerves. Because of the cancer location, reconstruction of the left phrenic nerve was not possible, so to prevent the patient's ventilator dependence, the right phrenic nerve was reconstructed via an autograft from the residual proximal stump of the contralateral one. In 3 months, the right hemidiaphragm function showed a full recovery, documented by ultrasonographic and radiographic assessment of diaphragmatic excursion, and the patient was weaned from mechanical ventilation. When a nerve autogra...
Conclusion: Due to the limited number of reported cases in the literature, it is difficult to predict the outcomes of spinal SS. Further, different treatment modalities have been used to treat spinal SS. However, most of the reported cases had poor outcomes. Therefore, prospective multi-center studies are needed to further investigate the treatment strategies and outcomes for patients with spinal SS. PMID: 33024595 [PubMed]
Conclusions: In this large nationwide cohort, tumor size and tumor location were independent prognostic factors for OS. Furthermore, a higher probability of an RC tumor with increasing age was suggested. An increased use of RT over the years did not translate into improved OS for localized MLS. PMID: 33029074 [PubMed]
Condition: Keloid Interventions: Drug: Bleomycin; Drug: Normal saline Sponsors: Erasmus Medical Center; Centre for Human Drug Research, Netherlands Not yet recruiting
We describe the varied uses of hyaluronidase in dermatology and the underlying evidence base for its dermatological indications. This includes its uses in enhancing drug delivery (for local anesthesia, keloid and hypertrophic scars, and for Kaposi’s sarcoma), in the treatment of disorders associated with mucin deposition (myxedema, scleroderma, scleredema, and cutis verticis gyrata) and its potential uses in surgery (as a pre-operative adjuvant in dermatofibrosarcoma protuberans, for periorbital edema, and for hematomas). In select circumstances, hyaluronidase might be more efficacious than more established treatment...
Publication date: Available online 4 June 2020Source: The Annals of Thoracic SurgeryAuthor(s): Yur-Ren Kuo, Chih-Kai Yang, Austin Chen, Savitha Ramachandran, Sin-Daw Lin
Abstract Keloids are considered as benign fibroproliferative skin tumors and rare case of malignancies has been reported. Hereby, we present a case of low-grade myofibroblastic sarcoma arising from a recurrent painful keloid scar on the right chest wall after video-assisted thoracic surgery for pneumothorax in a 77-year-old man. Wide composite excision of the keloid and surrounding ribs, and partial diaphragm were performed. The chest wall pleural defect was reconstructed with Teflon, and soft tissue was reconstructed with a transverse rectus abdominis myocutaneous flap. This case highlights that refractory keloid...
CONCLUSION: DFS is a common cancer with a good outcome if managed earliest. Delayed diagnoses and inadequate first-time surgery led to tumor extension and recurrences. Locally advanced tumors management needs extensive resections and reconstructive surgery. In addition to surgery, Imatinib and radiotherapy improve outcomes, but are not available in our context. PMID: 32059813 [PubMed - as supplied by publisher]