Oral ulcers caused by the use of methotrexate in a patient with rheumatoid arthritis

Methotrexate is a chemotherapy originally used in oncology that is also applied in several nononcologic diseases, such as rheumatoid arthritis, because it has an anti-inflammatory effect in low doses. A 68-year-old leucoderm man attended our service with complaint of oral sores for 1 month. As a personal background he had rheumatoid arthritis, diabetes, hypertension, and hypothyroidism. The patient said the ulcers began to appear after the dose of methotrexate had been changed. Clinical history and anamnesis as well as a conversation with his physician led to the conclusion that a possible methotrexate toxicity was related to the oral ulcers despite the use of the medication in low doses (25 mg weekly).
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: 20190672 Source Type: research

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