EP News: Clinical

Knopps et  al (N Engl J Med 2020;383:526–536, PMID 32757521) conducted a noninferiority trial in patients with an indication for an implantable cardioverter-defibrillator (ICD) but no indication for pacing. Patients (N = 849) were randomized to receive a subcutaneous ICD (S-ICD; n = 426) or transvenous ICD (T-ICD; n = 423). The primary endpoint was the composite of device-related complications and inappropriate shocks. Secondary endpoints included death and appropriate shocks. Over 49.1 months, a primary endpoint event occurred in 68 S-ICD patients and 68 T-ICD patients (48-month incidence 15.1% and 15.7%, respectively; hazard ratio [HR] 0.99; P = .01 for noninferiority; P = .95 for superiority).
Source: Heart Rhythm - Category: Cardiology Authors: Tags: EP NEWS Source Type: research
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