Facilitating islet transplantation using a three-step approach with mesenchymal stem cells, encapsulation, and pulsed focused ultrasound

The aim of this study was to examine the effect of a three-step approach that utilizes the application of adipose tissue-derived mesenchymal stem cells (AD-MSCs), encapsulation, and pulsed focused ultrasound (...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research

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Conclusions: The delivery of PHD2 shRNA-modified BMSCs by UTMD promoted grafted cell homing and activity, and increased myocardial angiogenesis in the infarcted heart, leading to improved cardiac function. This combination may provide a promising strategy for enhancing the effectiveness of stem cell therapy after acute myocardial infarction.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Veno-occlusive disease (VOD) is a severe complication of allogeneic stem cell transplantation (allo-SCT). Its diagnosis is difficult, and ultrasound (US) has not been proven to be of additional diagnostic value. In the work described here, we prospectively analyzed the hepatic contrast-enhanced ultrasound (CEUS) pattern before and after allo-SCT and correlated these results with the pre-allo-SCT VOD risk factors, clinical VOD findings and conventional US findings. Thirty consecutive patients who underwent allo-SCT and had at least one VOD risk factor were studied.
Source: Ultrasound in Medicine and Biology - Category: Radiology Authors: Tags: Original Contribution Source Type: research
Recently stem cell therapy has been explored extensively as a promising treatment for decompensated liver cirrhosis. However, the progress of stem cell transplantation was hindered ascribe to genomic instability and low obtaining efficiency of cultured stem cells. Moreover, it is pivotal to optimizing transplantation routes by which the stem cells can be delivered effectively. Here fresh autologous bone marrow transplantation (BMT) through intraportal route guided by Endoscopic ultrasound (EUS) was utilized to achieve therapeutic goals in patients with decompensated liver cirrhosis.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstracts Source Type: research
In conclusion, elevated brain amyloid was associated with family history and APOE ε4 allele but not with multiple other previously reported risk factors for AD. Elevated amyloid was associated with lower test performance results and increased reports of subtle recent declines in daily cognitive function. These results support the hypothesis that elevated amyloid represents an early stage in the Alzheimer's continuum. Blood Metabolites as a Marker of Frailty https://www.fightaging.org/archives/2020/04/blood-metabolites-as-a-marker-of-frailty/ Frailty in older people is usually diagnosed in a sympt...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion:The combination therapy, which involved treatment with ASC and 300  mV LOFUS, quickly and effectively reduced articular cartilage defects.
Source: Tissue Engineering and Regenerative Medicine - Category: Biotechnology Source Type: research
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Source: Pediatric Hematology and Oncology - Category: Pediatrics Authors: Source Type: research
Abstract The current treatment for liver failure is restricted to surgical liver transplantation, which is technically complicated, limited by the shortage of available organs and presents major risks to the patient. Bone marrow mesenchymal stem cells (BMSCs) represent promising sources of hepatocyte-like cells for cell transplantation treatment. However, a safe and efficient induction method for their differentiation remains to be defined. Here we further optimized an effective technique by combining high-dose treatment with hepatocyte growth factor (HGF) and ultrasound stimulation. The optimized ultrasound param...
Source: Radiation Research - Category: Physics Authors: Tags: Radiat Res Source Type: research
Conclusion Several ultrasound variables can be used as predictors for a patient's risk of developing SOS. The strongest predictors are ascites severity, main portal vein velocity, common hepatic artery peak systolic velocity, and left hepatic artery peak systolic velocity.
Source: Ultrasound Quarterly - Category: Radiology Tags: Original Research Source Type: research
CONCLUSION: In our study, conditioning regimens, acute and chronic hepatic GVHD are frequent causes of hepatic injury following allogeneic HSCT while conditioning regimens, flare of viral hepatitis, and sepsis represent the most common causes of hepatic injury following autologous HSCT. PMID: 32372257 [PubMed - in process]
Source: J Egypt Natl Canc In... - Category: Cancer & Oncology Authors: Tags: J Egypt Natl Canc Inst Source Type: research
In this study, we demonstrated that FUS increases MSC transplantation into brain tissue by>2-fold, and that this finding might be related to the activation of intercellular adhesion molecule-1 in endothelial and subendothelial cells and vascular adhesion molecule-1 in endothelial cells.Graphical abstract
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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