Higher specificity of the new EULAR/ACR 2019 criteria for diagnosing systemic lupus erythematosus in patients with biopsy-proven cutaneous lupus.

CONCLUSIONS: The EULAR/ACR 2019 criteria are characterised by higher specificity for SLE diagnosis when compared to previously introduced criteria sets. We conclude that patients with CLE, even those meeting the criteria for SLE, have low risk of serious complications of SLE. PMID: 32940207 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

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CONCLUSIONS: Young adult IS patients in Korea exhibit low awareness and poor management of their risk factors. Although the short-term outcome was relatively favorable in those patients, having SLE was associated with unfavorable outcomes. More attention needs to be paid for improving awareness and controlling risk factors in this population. PMID: 33029967 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
Authors: Li H, Zhang J, Chen Y PMID: 33034436 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
This article reviews the recent advances of SFKs in B lymphocytes in autoimmune diseases.
Source: Inflammation - Category: Allergy & Immunology Source Type: research
Condition:   Systemic Lupus Erythematosus Interventions:   Drug: Sirolimus;   Drug: Placebo Sponsors:   Chinese SLE Treatment And Research Group;   Beijing Municipal Science & Technology Commission;   North China Pharmaceutical Group Corporation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 7 October 2020Source: The Egyptian RheumatologistAuthor(s): Samar H. Goma, Naima M. Mostafa, Nadia M Ismail, Salma Taha, Zeinab A. Abd Elhameed, Shimaa Khidr, Maha Abdelrahman
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
Condition:   Systemic Lupus Erythematosus Interventions:   Drug: Sirolimus;   Drug: Placebo Sponsors:   Chinese SLE Treatment And Research Group;   Beijing Municipal Science & Technology Commission;   North China Pharmaceutical Group Corporation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: In pSS, autoimmune CHB could be one of the first "indirect" signs of the disease in women of childbearing-age, in whom the diagnosis is confirmed several years later. Some maternal characteristics could be related with recurrent CHB, such as having an already-confirmed diagnosis of pSS and carrying the two Ro/La autoantibodies. PMID: 33025893 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Comorbidity and health care utilisation in persons with Sjögren's syndrome: a claims data analysis. Clin Exp Rheumatol. 2020 Sep 18; Authors: Albrecht K, Dörner T, Redeker I, Karberg K, Marschall U, Zink A, Callhoff J Abstract OBJECTIVES: To capture comorbidity and medication of persons with Sjögren's syndrome (SS) in a population-based cohort in comparison to matched controls. METHODS: Individuals with an outpatient diagnosis of M35.0 (ICD-10) in ≥2 quarters of a year or an inpatient diagnosis of M35.0 were identified in a German statutory health insurance fund covering 7.2 milli...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
We report the case of an elderly male with SSc-SLE overlap syndrome combined with scleroderma renal crisis and SSc-TMA. Diagnoses: The patient has typical of SSc on the face and hands, combined with pulmonary artery hypertension, interstitial lung disease, heart failure and malignant hypertension, as well as SLE, lupus nephritis class V, and TMA, which were definitively diagnosed by clinical laboratory examination and renal histopathology. Interventions: The patient was treated with prednisone, cyclophosphamid, renin-angiotensin system inhibitors, diuretics, and acetylcysteine. Outcomes: The patient died suddenly ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
In this study, we focus on the relationship between IKZF1 polymorphisms and SLE susceptibility, cytokine levels, and clinical characteristics in the Chinese Han population. One thousand seventy-six subjects, including 400 SLE patients and 676 healthy controls, were included in this study. Three single nucleotide polymorphisms within IKZF1 containing rs4917014, rs11980379, and rs4132601 were genotyped in all subjects by an improved multiplex ligation detection reaction technique. 143 subjects from SLE patients were randomly selected for testing the levels of serum cytokines. The clinical characteristics of SLE patients wer...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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