How inverting β-1,4-galactosyltransferase-1 can quench a high charge of the by-product UDP3− in catalysis: a QM/MM study of enzymatic reaction with native and UDP-5′ thio galactose substrates

Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01490G, PaperJ. K óňa The function of Asp252 in the catalysis of β-1,4-galactosyltransferase-1 may be the stabilization of a high charge of the by-product UDP3 − by a substrate-assisted proton transfer reaction. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research