Hyperlipoproteinemia (a) is associated with breast cancer in a Han Chinese population

This study included 314 breast cancer patients, 51 patients with benign breast tumors, and 185 healthy control subjects. All study subjects were Han Chinese with similar socio-economic backgrounds, who were local residents of Zhoushan, Zhejiang, China or who had lived in Zhoushan for a long period of time. Serum concentrations of LP(a) were determined using a latex-enhanced immunoturbidimetric assay. Clinicopathological characteristics of patients were retrieved from medical records, which included the histopathological type, grade, stage, and molecular subtype of the disease, the expression of estrogen receptor (ER), progesterone receptor (PR), HER2, and Ki67, and the level of reproductive hormones. Correlations between 2 groups were evaluated using the Spearman correlation analysis. Associations among ≥3 groups were interpreted using the Kruskal-Wallis H test or the logistic regression test. Elevated serum LP(a) levels were detected in breast cancer patients compared with healthy control subjects, but no significant differences in LP(a) were detected between breast cancer and benign tumor or between benign tumor and healthy control. In breast cancer patients, serum LP(a) levels were inversely associated with HER2 expression, but they were not significantly correlated with any other clinicopathologic characteristics of breast cancer evaluated in this study. Elevated serum LP(a) levels were associated with breast cancer in a Han Chinese population.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

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Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Mol Ther Methods Clin Dev Source Type: research
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Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
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Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
Nano LettersDOI: 10.1021/acs.nanolett.0c02644
Source: Nano Letters - Category: Nanotechnology Authors: Source Type: research
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Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Molecular Bases of Disease Source Type: research
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: J Cancer Res Clin Oncol Source Type: research
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Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: J Cancer Res Clin Oncol Source Type: research
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Source: The British Journal of Surgery - Category: Surgery Authors: Tags: Br J Surg Source Type: research
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Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
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