A review of methods for the reconstruction and analysis of integrated genome-scale models of metabolism and regulation.

A review of methods for the reconstruction and analysis of integrated genome-scale models of metabolism and regulation.
Biochem Soc Trans. 2020 Sep 17;:
Authors: Cruz F, Faria JP, Rocha M, Rocha I, Dias O
Abstract
The current survey aims to describe the main methodologies for extending the reconstruction and analysis of genome-scale metabolic models and phenotype simulation with Flux Balance Analysis mathematical frameworks, via the integration of Transcriptional Regulatory Networks and/or gene expression data. Although the surveyed methods are aimed at improving phenotype simulations obtained from these models, the perspective of reconstructing integrated genome-scale models of metabolism and gene expression for diverse prokaryotes is still an open challenge.
PMID: 32940659 [PubMed - as supplied by publisher]

Source: Biochemical Society Transactions - September 16, 2020 Category: Biochemistry Authors: Cruz F, Faria JP, Rocha M, Rocha I, Dias O Tags: Biochem Soc Trans Source Type: research