Rhodium-Catalyzed Cyclisation of Terminal and Internal Allenols: An Atom Economic and Highly Stereoselective Access Towards Tetrahydropyrans Johannes P. Schmidt, Bernhard Breit.

Rhodium-Catalyzed Cyclisation of Terminal and Internal Allenols: An Atom Economic and Highly Stereoselective Access Towards Tetrahydropyrans Johannes P. Schmidt, Bernhard Breit.
Angew Chem Int Ed Engl. 2020 Sep 17;:
Authors: Breit B, Schmidt J
Abstract
A comprehensive study of a diastereoselective Rh-catalyzed cyclization of terminal and internal allenols is reported. The methodology allows the atom economic and highly syn -selective access to synthetically important 2,4-disubstituted, respectively 2,4,6-trisubstituted tetrahydropyrans (THP). Furthermore, its utility and versatility is demonstrated by a great functional group compatibility and the enantioselective total synthesis of (-)-centrolobine.
PMID: 32940396 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - September 16, 2020 Category: Chemistry Authors: Breit B, Schmidt J Tags: Angew Chem Int Ed Engl Source Type: research