Relevance of glycoconjugates sulfotopes and their specific antibodies in Trypanosoma cruzi biological functions

Background: American trypanosomiasis or Chagas disease represents a major health problem and continues to be endemic in large areas of Latin America. The causal agent of this emergent parasitic infectious disease is Trypanosoma cruzi. At present, the amount of infected people worldwide projected the World Health Organization sums to 8 –10 million. T. cruzi contains a major antigen, cruzipain (Cz), with an unusual C-terminal extention (C-T), retained in the mature protein. C-T bears a number of post translational modifications and is responsible for the immunogenicity of the molecule.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0533 Source Type: research