Cancers, Vol. 12, Pages 2672: The Pancreatic Microbiome Is Associated with Carcinogenesis and Worse Prognosis in Males and Smokers

Cancers, Vol. 12, Pages 2672: The Pancreatic Microbiome Is Associated with Carcinogenesis and Worse Prognosis in Males and Smokers Cancers doi: 10.3390/cancers12092672 Authors: Jaideep Chakladar Selena Z. Kuo Grant Castaneda Wei Tse Li Aditi Gnanasekar Michael Andrew Yu Eric Y. Chang Xiao Qi Wang Weg M. Ongkeko An intra-pancreatic microbiota was recently discovered in several prominent studies. Since pancreatic adenocarcinoma (PAAD) is one of the most lethal cancers worldwide, and the intratumor microbiome was found to be a significant contributor to carcinogenesis in other cancers, this study aims to characterize the PAAD microbiome and elucidate how it may be associated with PAAD prognosis. We further explored the association between the intra-pancreatic microbiome and smoking and gender, which are both risk factors for PAAD. RNA-sequencing data from The Cancer Genome Atlas (TCGA) were used to infer microbial abundance, which was correlated to clinical variables and to cancer and immune-associated gene expression, to determine how microbes may contribute to cancer progression. We discovered that the presence of several bacteria species within PAAD tumors is linked to metastasis and immune suppression. This is the first large-scale study to report microbiome-immune correlations in human pancreatic cancer samples. Furthermore, we found that the increased prevalence and poorer prognosis of PAAD in males and smokers are linked to the presence of potentia...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research