Predicting the future of liver-safe drugs

(Tokyo Medical and Dental University) Researchers at Tokyo Medical and Dental University (TMDU) working with an international team have developed a Polygenic Risk Score using previous genomic studies that may help predict drug-induced liver injury. This score was validated on genomic data, cell cultures and organoids for several potentially hepatotoxic drugs, and may inform a screening test that can predict adverse responses both to approved medications in clinical practice as well as to drug candidates in preliminary experimental trials.
Source: EurekAlert! - Biology - Category: Biology Source Type: news