Toxoplasma gondii infection damages the perineuronal nets in a murine model.

CONCLUSIONS: Our findings revealed a random distribution of cysts in the brain, the disruption of PNNs surrounding neurons in four areas of the cerebral cortex and hyperlocomotor behavior in T. gondii-infected mice. These results can contribute to elucidate the link toxoplasmosis with the establishment of neuroinflammatory response in neuropsychiatric disorders and to raise a discussion about the mechanisms related to changes in brain connectivity, with possible behavioral repercussions during chronic T. gondii infection.
PMID: 32935749 [PubMed - indexed for MEDLINE]

Source: Memorias do Instituto Oswaldo Cruz - September 18, 2020 Category: Infectious Diseases Authors: Meurer YDSR, Brito RMM, da Silva VP, Andade JMA, Linhares SSG, Pereira Junior A, de Andrade-Neto VF, de Sá AL, Oliveira CBS Tags: Mem Inst Oswaldo Cruz Source Type: research