Voluntary wheel running can lead to modulation of immune checkpoint molecule expression.

CONCLUSION: B16 tumors displayed upregulated expression of immune regulatory molecules and decreased tumor growth in response to PA. However, combining PA with PD-1 or PD-L1 blockade did not lead to a further augmented inhibition of tumor growth.
PMID: 32935602 [PubMed - as supplied by publisher]

Source: Acta Oncologica - September 15, 2020 Category: Cancer & Oncology Authors: Bay ML, Unterrainer N, Stagaard R, Pedersen KS, Schauer T, Staffeldt MM, Christensen JF, Hojman P, Pedersen BK, Gehl J Tags: Acta Oncol Source Type: research