Signalosome-Regulated SRF Phosphorylation Determining Myocyte Growth in Width versus Length as a Therapeutic Target for Heart Failure.

Conclusions: We have identified a new molecular switch, namely mAKAPβ signalosome-regulated SRF phosphorylation, that controls a transcriptional program responsible for modulating changes in cardiac myocyte morphology that occur secondary to pathological stressors. Complementary AAV-based gene therapies constitute rationally-designed strategies for a new translational modality for heart failure.
PMID: 32933333 [PubMed - as supplied by publisher]

Source: Circulation - September 15, 2020 Category: Cardiology Authors: Li J, Tan Y, Passariello CL, Martinez EC, Kritzer MD, Li X, Li X, Li Y, Yu Q, Ohgi K, Thakur H, MacArthur JW, Ivey JR, Woo YJ, Emter CA, Dodge-Kafka K, Rosenfeld MG, Kapiloff MS Tags: Circulation Source Type: research