Iron induces cell death and strengthens the efficacy of anti-androgen therapy in prostate cancer models.

CONCLUSIONS: Our models allow us to dissect the direct iron effect on cancer cells. We demonstrate the proof of principle that iron toxicity inhibits PCa cell proliferation, proposing a novel tool to strengthen anti-androgen treatment efficacy.
PMID: 32928793 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - September 13, 2020 Category: Cancer & Oncology Authors: Bordini J, Morisi F, Elia AR, Santambrogio P, Pagani A, Cucchiara V, Ghia P, Bellone M, Briganti A, Camaschella C, Campanella A Tags: Clin Cancer Res Source Type: research