Steroid sulfatase stimulates intracrine androgen synthesis and is a therapeutic target for advanced prostate cancer.

CONCLUSIONS: These studies suggest that STS drives intracrine androgen synthesis and prostate cancer proliferation. Targeting STS represents a therapeutic strategy to treat CRPC and improve second generation anti-androgen therapy.
PMID: 32928794 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - September 13, 2020 Category: Cancer & Oncology Authors: Gao AC, Armstrong CM, Liu C, Liu L, Yang JC, Lou W, Zhao R, Ning S, Lombard AP, Zhao J, D'Abronzo LS, Evans CP, Li PK Tags: Clin Cancer Res Source Type: research