Personalized Hemodynamic Modeling of the Human Cardiovascular System: A Reduced-Order Computing Model

Conclusion: The model is efficient, versatile, and capable of obtaining well-fitting individualized pressure waveforms while reasonably predicting flow waveforms. Significance: The proposed methodology of personalized hemodynamic modeling may therefore facilitate individualized patient-specific assessment of both physiological and pathological functions of the CVS.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research

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This study aims to compare SBIs, deep white matter lesions (DWMLs), and periventricular white matter lesions (PWMLs) in ipsilateral and contralateral hemispheres to internal carotid artery (ICA) stenosis, and investigate their association with stenosis grade in patients with asymptomatic  ≥ 50% unilateral extracranial ICA stenosis. Patients without previous history of stroke and/or transient ischemic attack who had ≥ 50% stenosis in unilateral ICA on carotid color Doppler ultrasound were enrolled in the study. Patient demographics, vascular risk factors and ICA stenosis grades; number, loc...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
The rapid development of medical technology affects every aspect of medicine and healthcare. Even the seemingly most remote and ivory-tower-like institution isn’t impervious to digital health disruption. We are, of course, talking about the pharmacy.  Although these institutions play a crucial role in the healing process, the impression about pharmacists and their drug store is often that they offer a type of commercial/business-like service. The doctor prescribes the appropriate medicine with the appropriate instructions, and the pharmacist provides it in exchange for money. In short, a clear business. However,...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Digital Health Research E-Patients Future of Medicine Future of Pharma Healthcare Design Telemedicine & Smartphones 3d printing DTC Personalized medicine gc4 pharmacies drug development viatom checkme pro drugs lumify philips Source Type: blogs
This study is the first to explore the clinical potential of measuring BTPs using ultrasound in acute ischemic stroke patients.BTPs were measured in 24 healthy volunteers (aged 52 –82 years) and 14 acute ischemic stroke patients (aged 51–86 years) using a novel Transcranial Tissue Doppler (TCTD) method. Measurements were quick to perform and were well tolerated by all subjects.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research
EchoNous, a developer of novel ultrasounds, has found a way to leverage multiple critical clinical technologies within a single device. The result is KOSMOS, a handheld 3-in-1 device consisting of an ultrasound, electronic stethoscope, and an ECG, al...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiology Critical Care Diagnostics Exclusive Informatics Medicine Public Health Source Type: blogs
Authors: Kotteduwa Jayawarden S, Sandarage R, Farag J, Ganzert C, Winston P, Mills P, Reebye R Abstract OBJECTIVE: To investigate changes in hemiparetic gait parameters after treatment of elbow flexor spasticity with botulinum neurotoxin (BoNT) injection and adjunctive casting. DESIGN: Prospective case series. SUBJECTS: Ten participants with spasticity secondary to acquired brain injury (8 stroke, 2 traumatic brain injury). INTERVENTIONS: Participants received BoNT injections for their spastic elbow flexors under ultrasound guidance. Two weeks post-injection, an elbow stretching cast was applied for 1 w...
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
This study recruited 30 patients with dysphagia after stroke. The JOE group performed a JOE using a resistance bar. The HLE group performed the traditional HLE. The total intervention duration was 6 weeks. We measured the thickness of the digastric and mylohyoid muscles using ultrasound. Two-dimensional motion analysis of the hyoid bone was performed using Image J software. The Borg rating of the perceived exertion scale was used to assess the intensity level of physical activity during the 2 exercises. Both groups showed a significant increase in the thickness of the digastric and mylohyoid muscles (P 
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
AbstractPurposeThe interdisciplinary German guidelines for the diagnosis and treatment of internal carotid artery stenosis (ICAS) recommend a multiparametric approach for the sonographic grading of extracranial ICAS. The aim of this study is to evaluate the interrater and intermethod agreement of this elaborated sonographic approach with different angiographic modalities.MethodsPatients with extracranial ICAS were examined twice with colour-coded duplex sonography (CDS) by two experienced vascular neurologists. Each of the ten criteria and the resulting stenotic value were assessed. Grading of ICAS based on the multiparame...
Source: Neuroradiology - Category: Radiology Source Type: research
Conditions:   Stroke;   Spasticity, Muscle;   Botulism;   Ultrasound;   Activity of Daily Living Intervention:   Drug: Botulinum toxin injection Sponsor:   National Taiwan University Hospital Not yet recruiting
Source: - Category: Research Source Type: clinical trials
DISCUSSION:  VWF:Ag expression, a marker of endothelial ± platelet activation, is enhanced in recently symptomatic versus asymptomatic carotid stenosis patients, including in MES-ve patients, and decreases with ADAMTS13 activity over time following atherosclerotic TIA/ischemic stroke. PMID: 32932544 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: Thromb Haemost Source Type: research
Conditions:   Traumatic Brain Injury;   Subarachnoid Hemorrhage;   Intracerebral Hemorrhage;   Liver Failure;   Ischemic Stroke Intervention:   Diagnostic Test: Transcranial Doppler Sponsors:   Duke University;   University of California, San Francisco Recruiting
Source: - Category: Research Source Type: clinical trials
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