Autopsy Findings in 32 Patients with COVID-19: A Single-Institution Experience

Conclusion: This series of autopsies from patients with COVID-19 confirms the observation that the majority of severely affected patients have significant pulmonary pathology. However, many patients also have widespread microscopic thromboses, as well as characteristic findings in the liver and lymph nodes.Pathobiology
Source: Pathobiology - Category: Pathology Source Type: research

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CONCLUSION: Patients aged ≥ 70 years, those with fever on admission, and patients with an underlying malignancy or diabetes were found to be more likely to succumb to COVID-19. Elderly in care facilities or hospitalized patients with an underlying disease should receive more attention and be considered for preventive quarantine. PMID: 32924343 [PubMed - in process]
Source: J Korean Med Sci - Category: General Medicine Authors: Tags: J Korean Med Sci Source Type: research
AbstractCOVID-19 is an infectious respiratory disease which firstly occurred in Wuhan, China and evolved rapidly around the globe. The causative pathogen is a novel coronavirus called SARS-CoV-2 with genomic similarities with SARS-CoV and MERS-CoV. The disease is transmitted among humans either through direct contact or via droplets from sneeze or cough. Most infected persons remain asymptomatic or mildly symptomatic, but some patients may develop severe clinical features, including pneumonia, respiratory failure, sepsis and even death. People of advanced age and/or with underlying diseases (including diabetes mellitus) ar...
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
Conclusion and Relevance: In this single-center case series from New Delhi, out of 82 patients of SARI, 32 patients were confirmed NCIP, with a COVID-19 positivity of 39%. 75% of NCIP presented in severe pneumonia and 37.5% required ICU care. The case fatality rate was 28%. PMID: 32602676 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
This study aims to investigate, retrospectively, the epidemiological and clinical characteristics, laboratory results, radiologic findings and outcomes of novel coronavirus disease-19 (COVID-19) in patients with transfusion dependent β thalassemia (β-thalassemia major-TM), non-transfusion dependent β thalassemia (β-thalassemia intermedia -TI) and sickle cell disease (SCD).Design, setting:A total of 17 Centers, from 10 countries, following 9,499 patients with hemoglobinopathies participated in the survey.Main outcome measures:Clinical, laboratory and radiologic findings and outcomes of patients with COVI...
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Authors: Source Type: research
This study aims to investigate, retrospectively, the epidemiological and clinical characteristics, laboratory results, radiologic findings and outcomes of novel coronavirus disease-19 (COVID-19) in patients with transfusion dependent ? thalassemia (?-thalassemia major-TM), non-transfusion dependent ? thalassemia (?-thalassemia intermedia -TI) and sickle cell disease (SCD).Design, setting:A total of 17 Centers, from 10 countries, following 9,499 patients with hemoglobinopathies participated in the survey.Main outcome measures:Clinical, laboratory and radiologic findings and outcomes of patients with COVID-19 were collected ...
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Authors: Source Type: research
CONCLUSIONS: SARS-Cov-2 has emerged as a worldwide threat, currently affecting 170 countries and territories across the globe. There is still much to be understood regarding SARS-CoV-2 about its virology, epidemiology and clinical management strategies; this knowledge will be essential to both manage the current pandemic and to conceive comprehensive measures to prevent such outbreaks in the future. PMID: 32495923 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
A 50 year-old man with controlled hypertension and type II diabetes presented after one week of dyspnea and cough with a blood O2 saturation of 90%. A reverse ttranscriptase-polymerase chain eaction assay on a nasopharyngeal swab specimen confirmed severe acute respiratory syndrome coronavirus 2, and a diagnosis of coronavirus disease 2019 (COVID-19) pneumonia. On initial neurologic examination, the patient was alert and fully oriented with fluent speech and no focal deficits. On the second hospital day and while on 2L of supplemental O2 through nasal cannula, blood O2 saturation dropped to 70% and he was intubated.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
A 50 year-old man with controlled hypertension and type II diabetes presented after one week of dyspnea and cough with a blood O2 saturation of 90%. A Reverse Transcriptase-Polymerase Chain Reaction assay on a nasopharyngeal swab specimen confirmed severe acute respiratory syndrome coronavirus 2, and a diagnosis of coronavirus disease 2019 (COVID-19) pneumonia. On initial neurologic examination, the patient was alert and fully oriented with fluent speech and no focal deficits. On the second hospital day and while on 2L of supplemental O2 through nasal cannula, blood O2 saturation dropped to 70% and he was intubated.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) associated disease (COVID-19), recently reported in Wuhan, is causing an unprecedented pandemia. Patients typically present with fever, cough and dyspnea. Advanced age, cardiovascular disease (CVD), diabetes (DM) and lung disease (LD) have been related with worse clinical outcome [1].
Source: Lung Cancer - Category: Cancer & Oncology Authors: Tags: Correspondence Source Type: research
An 84-year-old woman with a diameter of 10  mm irregular subsolid nodule in the right middle lobe on computed tomography (CT) images of the chest (Figure 1, A1) was confirmed to have T1b N0 M0 lung adenocarcinoma after thoracoscopic right middle lobectomy on January 14. She had 20-year history of hypertension and diabetes and her pulmonary function testing was normal before surgery. This patient complained of cough, expectoration, and dyspnea the next day but no any signs of pneumonia displayed on her chest CT images (Figure 1, A2).
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Case Report Source Type: research
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