Blocking CTGF-Mediated Tumor-Stroma Interplay in Pancreatic Cancer.

Blocking CTGF-Mediated Tumor-Stroma Interplay in Pancreatic Cancer.
Trends Mol Med. 2020 Sep 11;:
Authors: Shen YW, Zhou YD, Luan X, Zhang WD
Abstract
As the major feature of pancreatic ductal adenocarcinoma (PDAC), desmoplastic stroma poses a significant obstacle for treatment. Recent studies revealed that connective tissue growth factor (CTGF) aggravates the fibrotic environment and drives cancer initiation and progression, thus suggesting CTGF as a novel target for PDAC treatment.
PMID: 32928643 [PubMed - as supplied by publisher]

Source: Trends in Molecular Medicine - September 10, 2020 Category: Molecular Biology Authors: Shen YW, Zhou YD, Luan X, Zhang WD Tags: Trends Mol Med Source Type: research