Prevalence of low bone mineral density in inflammatory bowel disease and factors associated with it

AbstractBackgroundPatients with inflammatory bowel disease (IBD) have numerous risk factors for low bone mineral density (BMD). We aimed to study the prevalence of low BMD in IBD and the factors associated with it.MethodsBMD was measured by radial quantitative ultrasound, and clinical and biochemical characteristics were compared in prospectively enrolled patients and healthy age and gender-matched controls. Chi-square test,t test for independent samples, analysis of variance (ANOVA), Mann –WhitneyU test and Kruskal –WallisH tests were used as appropriate for univariate analysis to compare the characteristics between patients with and without abnormal BMD. Binary logistic regression analysis was done to determine the factors associated with low BMD in IBD patients.ResultsOne hundred and six patients (Crohn ’s disease [CD] = 35, ulcerative colitis [UC] = 71) and 55 controls were included. Low BMD was equally prevalent in CD, UC and controls (42.9%, 36.6%, 36.4% respectively,p = 0.791). Serum calcium and vitamin D were significantly lower in IBD patients compared to controls (p 
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research

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Conclusions: Anorectal function is impaired in IBD patients with perianal disease. Fecal incontinence correlates with poorer quality of life. Anorectal manometry and ultrasonography are useful tools for evaluating IBD patients. PMID: 31625422 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - Category: Surgery Tags: J Invest Surg Source Type: research
CONCLUSION: In this study, we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population. PMID: 31602167 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Crohn's disease and ulcerative colitis are chronic inflammatory diseases that lead to progressive bowel damage including the development of stricturing and penetrating complications. Increasingly, cross-sectional imaging with computed tomography or magnetic resonance scans have emerged as leading tools to: (1) assess disease activity; (2) monitor response to therapy or disease recurrence; and (3) identify disease-related complications. Several validated radiological scoring systems have been developed to quantify cross-sectional and longitudinal inflammatory burden in these diseases and to monitor response to treatment. Bo...
Source: Gastrointestinal Endoscopy Clinics of North America - Category: Gastroenterology Authors: Source Type: research
We present these recommendations, based on the current evidence for radiologic management in this group, and propose an imaging algorithm for investigating VEO-IBD.
Source: Pediatric Radiology - Category: Radiology Source Type: research
Conditions:   Crohn Disease;   Ulcerative Colitis Intervention:   Procedure: Endoscopic ultrasound catheter (UM-2R/3R, Olympus) Sponsor:   Carilion Clinic Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
I remember the moment I first saw a female chest X-ray. It was my own. My lecturers in the first months of medical school showed a few chest films, but I failed to recognize that the bodies all looked the same. I proudly showed my sister my clear lungs. She laughed and said, “I can see your boobs.” I looked again at mine with new eyes, taking in the dull, gray color of adipose tissue that I had never seen before. Something was missing from all the previous images I had seen: diversity. As second years, we practiced procedures on each other to gain experience before working with patients. We did abdominal ultras...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Education Hospital-Based Medicine Pediatrics Primary Care Source Type: blogs
Conclusion Analysis of bowel microvascularization by CEUS shows statistically significant changes in the wash-in-rate related to response of vedolizumab therapy. PMID: 29345146 [PubMed - as supplied by publisher]
Source: Acta Radiologica - Category: Radiology Authors: Tags: Acta Radiol Source Type: research
AbstractBackgroundThere is growing literature on the use of ultrasound (US) for evaluation of Crohn disease in adults, but few studies have been conducted on children. Several studies demonstrated high accuracy of US in the diagnosis of Crohn disease. Using US as the primary screening imaging modality for Crohn disease can reduce health care costs, the need for sedation and ionizing radiation exposure.ObjectiveThe aim of our study is to determine if US can be used for screening evaluation of pediatric Crohn disease.Materials and methodsA prospective cohort study of pediatric patients undergoing MR enterography (MRE) for su...
Source: Pediatric Radiology - Category: Radiology Source Type: research
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