In vitro and in vivo evaluation of an adamantyl-based phenyl sulfonyl acetamide against cutaneous leishmaniasis models of L. amazonensis.

In vitro and in vivo evaluation of an adamantyl-based phenyl sulfonyl acetamide against cutaneous leishmaniasis models of L. amazonensis.
Antimicrob Agents Chemother. 2020 Sep 14;:
Authors: Santos CC, Zhang H, Batista MM, de Oliveira GM, Demarque KC, da Silva-Gomes NL, Moreira OC, Ogungbe IV, Soeiro MNC
Abstract
Phenotypic assay against L. amazonensis in vitro and in vivo led to identification of an adamantyl-based phenyl sulfonyl acetamide (1) as a promising antileishmanial agent. Compound 1 inhibited the growth of intracellular forms of L. amazonensis (IC50 4 μM), exhibited low toxicity to host cells, with selectivity index >125. However, in cutaneous leishmaniasis mouse model, 1 did not reduce lesions and parasite load when administered as monotherapy or given simultaneously with suboptimal dose of miltefosine.
PMID: 32928731 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - September 13, 2020 Category: Microbiology Authors: Santos CC, Zhang H, Batista MM, de Oliveira GM, Demarque KC, da Silva-Gomes NL, Moreira OC, Ogungbe IV, Soeiro MNC Tags: Antimicrob Agents Chemother Source Type: research