In Vivo Pharmacodynamic Target Assessment of Antofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a Neutropenic Murine Pneumonia Model.

In Vivo Pharmacodynamic Target Assessment of Antofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a Neutropenic Murine Pneumonia Model.
Antimicrob Agents Chemother. 2020 Sep 14;:
Authors: Zhou YF, Liu P, Dai SH, Sun J, Liu YH, Liao XP
Abstract
We determined in vivo efficacy and target PK/PD exposures of antofloxacin against S. pneumoniae and S. aureus in the murine pneumonia model. The mean plasma fAUC/MIC targets associated with stasis, 1-log10 and 2-log10 kill effects were 8.93, 19.2 and 48.1 for S. pneumoniae; whereas they were 30.5, 55.4 and 115.8 for S. aureus The fAUC/MIC targets in murine lung epithelial lining fluids (ELF) for the same endpoints were nearly 2-fold higher than those in plasma.
PMID: 32928734 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - September 13, 2020 Category: Microbiology Authors: Zhou YF, Liu P, Dai SH, Sun J, Liu YH, Liao XP Tags: Antimicrob Agents Chemother Source Type: research