Cancers, Vol. 12, Pages 2651: Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research

Cancers, Vol. 12, Pages 2651: Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research Cancers doi: 10.3390/cancers12092651 Authors: Sirin Saranyutanon Sachin Kumar Deshmukh Santanu Dasgupta Sachin Pai Seema Singh Ajay Pratap Singh We have witnessed noteworthy progress in our understanding of prostate cancer over the past decades. This basic knowledge has been translated into efficient diagnostic and treatment approaches leading to the improvement in patient survival. However, the molecular pathogenesis of prostate cancer appears to be complex, and histological findings often do not provide an accurate assessment of disease aggressiveness and future course. Moreover, we also witness tremendous racial disparity in prostate cancer incidence and clinical outcomes necessitating a deeper understanding of molecular and mechanistic bases of prostate cancer. Biological research heavily relies on model systems that can be easily manipulated and tested under a controlled experimental environment. Over the years, several cancer cell lines have been developed representing diverse molecular subtypes of prostate cancer. In addition, several animal models have been developed to demonstrate the etiological molecular basis of the prostate cancer. In recent years, patient-derived xenograft and 3-D culture models have also been created and utilized in preclinical research. This review is an attempt to succinctly discuss existing informat...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research