Genetic Characterization of Three Distinct Mechanisms Supporting RNA-Driven DNA Repair and Modification Reveals Major Role of DNA Polymerase ζ

Still much is unknown about the roles of RNA in DNA repair and modification. Meers et  al. characterize three genetic mechanisms by which RNA can directly or indirectly transfer genetic information to DNA in yeast cells and uncover that direct RNA-templated DNA recombination is aided by translesion DNA polymerase ζ.

Source: Molecular Cell - September 1, 2020 Category: Cytology Authors: Chance Meers, Havva Keskin, Gabor Banyai, Olga Mazina, Taehwan Yang, Alli L. Gombolay, Kuntal Mukherjee, Efiyenia I. Kaparos, Gary Newnam, Alexander Mazin, Francesca Storici Tags: Article Source Type: research